The German Football League (DFL) scheduled Matchdays 10 to 16 of the 2022/23 Bundesliga season on Friday. VfB play five of their fixtures at 15:30 CET on a Saturday. The Cannstatt boys also travel to Borussia Mönchengladbach on Friday on Matchday 13 and host Hertha BSC on Tuesday of the following week, with both of those games in early November kicking off at 20:30 CET.
| Matchday | Kick-off | Home | Guest |
|---|---|---|
| 1 | Sun, 07.08., 15:30 CEST | VfB Stuttgart | RB Leipzig |
| 2 | Sat, 13.08., 15:30 CEST | SV Werder Bremen | VfB Stuttgart |
| 3 | Sat, 20.08., 15:30 CEST | VfB Stuttgart | SC Freiburg |
| 4 | Sun, 28.08., 15:30 CEST | 1.FC Köln | VfB Stuttgart |
| 5 | Sat, 03.09., 15:30 CEST | VfB Stuttgart | FC Schalke 04 |
| 6 | Sat, 10.09., 15:30 CEST | FC Bayern München | VfB Stuttgart |
| 7 | Sat, 17.09., 15:30 CEST | VfB Stuttgart | Eintracht Frankfurt |
| 8 | Sat, 01.10., 15:30 CEST | VfL Wolfsburg | VfB Stuttgart |
| 9 | Sun, 09.10., 19:30 CEST | VfB Stuttgart | 1.FC Union Berlin |
| 10 | Sat, 15.10., 15:30 CEST | VfB Stuttgart | VfL Bochum |
| 11 | Sat, 22.10., 15:30 CEST | Borussia Dortmund | VfB Stuttgart |
| 12 | Sat, 29.10., 15:30 CEST | VfB Stuttgart | FC Augsburg |
| 13 | Fri, 04.11., 20:30 CET | Borussia Mönchengladbach | VfB Stuttgart |
| 14 | Tue, 08.11., 20:30 CET | VfB Stuttgart | Hertha BSC |
| 15 | Sat, 12.11., 15:30 CET | Bayer 04 Leverkusen | VfB Stuttgart |
| 16 | Sat, 21.01., 15:30 CET | VfB Stuttgart | 1.FSV Mainz 05 |
| 17 | 24.-25.01. | TSG Hoffenheim | VfB Stuttgart |