VfB play four home games during this period, with both the Matchday 7 meeting against Baden-Württemberg rivals TSG Hoffenheim (2 October) and the clash with Arminia Bielefeld on Matchday 11 (6 November) taking place at 15:30* on Saturdays. The game against 1. FC Union Berlin on Matchday 9 has been scheduled for Sunday 24 October (kick-off 17:30) and on Friday 26 November, VfB open Matchday 13 under the floodlights against 1. FSV Mainz 05 (20:30).
Away from home, Pellegrino Matarazzo’s men go to Borussia Mönchengladbach on Saturday 16 October (18:30), FC Augsburg on Sunday 31 October (15:30) and Borussia Dortmund on Saturday 20 November (15:30).
*all times CEST/CET
| Matchday | Date | Home | Away |
|---|---|---|
| 1 | Saturday 14.08., 15:30 CEST | VfB Stuttgart | SpVgg Greuther Fürth |
| 2 | Friday 20.08., 20:30 CEST | RB Leipzig | VfB Stuttgart |
| 3 | Saturday 28.08., 15:30 CEST | VfB Stuttgart | SC Freiburg |
| 4 | Sunday 12.09., 15:30 CEST | Eintracht Frankfurt | VfB Stuttgart |
| 5 | Sunday 19.09., 15:30 CEST | VfB Stuttgart | Bayer 04 Leverkusen |
| 6 | Sunday 26.09., 15:30 CEST | VfL Bochum | VfB Stuttgart |
| 7 | Saturday 02.10., 15:30 CEST | VfB Stuttgart | TSG Hoffenheim |
| 8 | Saturday 16.10., 18:30 CEST | Borussia Mönchengladbach | VfB Stuttgart |
| 9| Sunday 24.10., 17:30 CEST | VfB Stuttgart | 1.FC Union Berlin |
| 10 | Sunday 31.10., 15:30 CEST | FC Augsburg | VfB Stuttgart |
| 11 | Saturday 06.11., 15:30 CET | VfB Stuttgart | Arminia Bielefeld |
| 12 | Saturday 20.11., 15:30 CET | Borussia Dortmund | VfB Stuttgart |
| 13 | Friday 26.11., 20:30 CET | VfB Stuttgart | 1.FSV Mainz 05 |
| 14 | 03.-05.12. | VfB Stuttgart | Hertha BSC |
| 15 | 10.-12.12. | VfL Wolfsburg | VfB Stuttgart |
| 16 | 14./15.12. | VfB Stuttgart | FC Bayern München |
| 17 | 17.-19.12. | 1.FC Köln | VfB Stuttgart |