The next three games – away to 1. FSV Mainz 05 (26 September), at home to Bayer 04 Leverkusen (3 October) and away to Hertha BSC (17 October) – are also Saturday 15:30 CEST kick-offs.
Then come two Friday evening 20:30 local time starts – at home to 1. FC Köln (23 October) and away to Schalke on 30 October. The lads from Canstatt will then be back to Saturday 15:30 CET kick-offs, at home to Eintracht Frankfurt in the Mercedes-Benz Arena on 7 November and away to Baden-Württemberg rivals TSG Hoffenheim in a local derby on 21 November.
A week before the Bundesliga gets started, VfB will play their first match of the 2020/21 season in the DFB Cup on a date yet to be confirmed between 11 – 14 September. A trip to the winners of the Mecklenburg-Vorpommern Regional Cup awaits them.
| Matchday | Date | Home | Guest |
|---|---|---|
| 1 | Sat, 19.09., 15:30 CEST | VfB Stuttgart | SC Freiburg |
| 2 | Sat, 26.09., 15:30 CEST | 1.FSV Mainz 05 | VfB Stuttgart |
| 3 | Sat, 03.10., 15:30 CEST | VfB Stuttgart | Bayer 04 Leverkusen |
| 4 | Sat, 17.10., 15:30 CEST | Hertha BSC | VfB Stuttgart |
| 5 | Fri, 23.10., 20:30 CEST | VfB Stuttgart | 1.FC Köln |
| 6 | Fri, 30.10., 20:30 CET | FC Schalke 04 | VfB Stuttgart |
| 7 | Sat, 07.11., 15:30 CET | VfB Stuttgart | Eintracht Frankfurt |
| 8 | Sat, 21.11., 15:30 CET | TSG Hoffenheim | VfB Stuttgart |
| 9 | 27. - 30.11. | VfB Stuttgart | FC Bayern Munich |
| 10 | 04. - 07.12. | SV Werder Bremen | VfB Stuttgart |
| 11 | 11. - 13.12. | Borussia Dortmund | VfB Stuttgart |
| 12 | 15. - 16.12. | VfB Stuttgart | 1.FC Union Berlin |
| 13 | 18. - 21.12. | VfL Wolfsburg | VfB Stuttgart |
| 14 | 02. - 04.01.2021 | VfB Stuttgart | RB Leipzig |
| 15 | 08. - 11.01. | FC Augsburg | VfB Stuttgart |
| 16 | 15. - 17.01. | VfB Stuttgart | Borussia Mönchengladbach |
| 17 | 19. - 20.01. | Arminia Bielefeld | VfB Stuttgart |
