Saison:
| Platz | Spieler | Verein | Tore | |
|---|---|---|---|---|
| 1 | Luca Toni | FC Bayern München | 24 | |
| 2 | Mario Gomez | VfB Stuttgart | 19 | |
| 3 | Kevin Kuranyi | FC Schalke 04 | 15 | |
| 4 | Ivica Olic | Hamburger SV | 14 | |
| 4 | Markus Rosenberg | Werder Bremen | 14 | |
| 6 | Mladen Petric | Borussia Dortmund | 13 | |
| 6 | Diego | Werder Bremen | 13 | |
| 6 | Stanislav Sestak | VfL Bochum | 13 | |
| 6 | Marko Pantelic | Hertha BSC Berlin | 13 | |
| 10 | Rafael van der Vaart | Hamburger SV | 12 | |
| 11 | Grafite | VfL Wolfsburg | 11 | |
| 11 | Ioannis Amanatidis | Eintracht Frankfurt | 11 | |
| 11 | Franck Ribery | FC Bayern München | 11 | |
| 11 | Theofanis Gekas | Bayer 04 Leverkusen | 11 | |
| 11 | Hugo Almeida | Werder Bremen | 11 | |
| 16 | Szabolcs Huszti | Hannover 96 | 10 | |
| 16 | Miroslav Klose | FC Bayern München | 10 | |
| 16 | Artur Wichniarek | Arminia Bielefeld | 10 | |
| 16 | Mike Hanke | Hannover 96 | 10 | |
| 16 | Zvjezdan Misimovic | 1.FC Nürnberg | 10 | |
| 16 | Manasseh Ishiaku | MSV Duisburg | 10 | |
| 22 | Cacau | VfB Stuttgart | 9 | |
| 22 | Stefan Kießling | Bayer 04 Leverkusen | 9 | |
| 22 | Boubacar Sanogo | Werder Bremen | 9 | |
| 22 | Paolo Guerrero | Hamburger SV | 9 | |
| 26 | Sebastian Freis | Karlsruher SC | 8 | |
| 26 | Edin Dzeko | VfL Wolfsburg | 8 | |
| 26 | Tamas Hajnal | Karlsruher SC | 8 | |
| 26 | Ashkan Dejagah | VfL Wolfsburg | 8 | |
| 26 | Simon Rolfes | Bayer 04 Leverkusen | 8 |
