Saison:
| Platz | Spieler | Verein | Tore | |
|---|---|---|---|---|
| 1 | Theofanis Gekas | VfL Bochum | 20 | |
| 2 | Alexander Frei | Borussia Dortmund | 16 | |
| 2 | Roy Makaay | FC Bayern München | 16 | |
| 4 | Kevin Kuranyi | FC Schalke 04 | 15 | |
| 5 | Mario Gomez | VfB Stuttgart | 14 | |
| 5 | Mohamed Zidan | 1.FSV Mainz 05 | 14 | |
| 5 | Sergiu Radu | FC Energie Cottbus | 14 | |
| 5 | Marko Pantelic | Hertha BSC Berlin | 14 | |
| 9 | Cacau | VfB Stuttgart | 13 | |
| 9 | Diego | Werder Bremen | 13 | |
| 9 | Miroslav Klose | Werder Bremen | 13 | |
| 12 | Christian Gimenez | Hertha BSC Berlin | 12 | |
| 13 | Vlad Munteanu | FC Energie Cottbus | 11 | |
| 13 | Naohiro Takahara | Eintracht Frankfurt | 11 | |
| 15 | Andriy Voronin | Bayer 04 Leverkusen | 10 | |
| 15 | Artur Wichniarek | Arminia Bielefeld | 10 | |
| 17 | Aaron Hunt | Werder Bremen | 9 | |
| 17 | Euzebiusz Smolarek | Borussia Dortmund | 9 | |
| 17 | Ivan Saenko | 1.FC Nürnberg | 9 | |
| 20 | Stefan Kießling | Bayer 04 Leverkusen | 8 | |
| 20 | Jan Schlaudraff | Alemannia Aachen | 8 | |
| 20 | Claudio Pizarro | FC Bayern München | 8 | |
| 20 | Mike Hanke | VfL Wolfsburg | 8 | |
| 20 | Ioannis Amanatidis | Eintracht Frankfurt | 8 | |
| 20 | Rafael van der Vaart | Hamburger SV | 8 | |
| 20 | Markus Rosenberg | Werder Bremen | 8 | |
| 27 | Thomas Hitzlsperger | VfB Stuttgart | 7 | |
| 27 | Roberto Hilbert | VfB Stuttgart | 7 | |
| 27 | Zvjezdan Misimovic | VfL Bochum | 7 | |
| 27 | Sergej Barbarez | Bayer 04 Leverkusen | 7 |
